Proton Radiotherapy Verification and Dosimetry Applications

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Professor Stuart Green

Prof Stuart GreenStuart Green; Project Collaborator University Hospital Birmingham NHS Foundation Trust

Director of Medical Physics Birmingham University.

Honorary Professor

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Stuart Green is Head of the Medical Physics department of the University Hospital Birmingham, and an active researcher in the School of Physics and Astronomy.

Stuart has published more than 70 peer-reviewed papers as well as book chapters on various aspects of radiation measurements and on boron neutron capture therapy. He has received major grants from EPSRC and Cancer Research UK

He is a regular speaker on physics-based approaches to the treatment of cancer, including BNCT and proton and ion radiotherapy. He has recently completed a two year term as President of the British Institute of Radiology.

Qualifications

PhD Physics, 1988

MSc in The Physics and Technology of Nuclear Reactors, 1985

BSc Physics, 1984

Teaching

Teaching Programmes

Medical Radiation Physics

Physics and Technology of Nuclear Reactors

Postgraduate supervision

Stuart has supervised approximately ten PhD student projects, mainly in the areas of boron neutron capture therapy and particle therapy. He has also supervised more then 40 short (four month) Masters projects as part of the Birmingham MSc programmes.

Research

Research Themes

Stuarts research focuses on the development and clinical implementation of physics-based techniques for the treatment of cancer. These are mainly particle therapy, and boron neutron capture therapy, although Stuart also has interests ion other binary therapies and in conventional radiotherapy techniques. He has also been involved in work to use chemicals which can be analysed on the breath as markers of disease or treatment.

Research activity

Laser induced particle beams and LIBRA

Stuart is a Co-Applicant and a work-package coordinator for the EPSRC basic technology grant looking at the use of high power lasers as potential sources of particles for radiotherapy. This LIBRA consortium involves a large number of UK Universities and research institutes (see the LIBRA project site for more details.) with the Birmingham contribution being mainly related to accurate dosimetry of the emerging proton beams.

Boron Neutron Capture Therapy

Stuart is also a lead member of the Birmingham project to develop boron neutron capture therapy as a viable clinical option for treatment of highly invasive tumours which are poorly treated by conventional methods. Work on this project is currently following three main themes:

• Development of the University Dynamitron accelerator as a clinical treatment facility, with all necessary associated dosimetry

• Fundamental studies on the radiobiology of high and low LET radiations and the interaction between the damage which they produce

• Understanding and optimisation of the delivery of the novel boron carrier compound, BPA-Mannitol, to patients with certain kinds of brain tumour

Other activities

President of the British Institute of Radiology (2008-2010)

Member of the International Advisory Board of the Cockroft Institute (2009 - )

Member of the Panel advising on the content of the National Measurement System in Acoustics and Ionising Radiation (2006-  )

Member of the Board of Counsellors of the International Society for Neutron Capture Therapy (2004 - )

Publications

Roels, H., Konings, J., Green, S., Bradley, D.,Chettle, D., and Lauwerys, R. (1995) Time integrated blood-lead concentrations is a valid surrogate for estimating the cumulative lead dose assessed by tibial lead measurement. Environmental Research 69 75-82.

Edwards CR, Green S, Palethorpe JE, Mountford PJ. (1997) The response of a MOSFET, p-type semiconductor and LiF T:D to quasi-monoenergetoc x-rays. Physics in Medicine and Biology 42, 2383-2391.

Farajollahi A R, Bonnett DE, Tattam D, Green S. (2000) The potential use of polymer gel dosimetry in boron neutron capture therapy, Physics in Medicine and Biology, 45, N9-14.

Wojnecki C and Green S (2002). A preliminary comparative study of two treatment planning systems developed for Boron neutron capture Therapy: MacNCTPlan and SERA. Medical Physics 29, 8, 1710-1715

Culbertson CN, Green S , Mason AJ, Picton D, Baugh G, Hugtenburg RP, Yin Z, Scott MC, Nelson JM (2004) In-phantom Characterisation Studies at the Birmingham Accelerator-Generated epIthermal Neutron Source (BAGINS) BNCT Facility. Applied Radiation and Isotopes, 61, (2004) 733-738

Pappas E, Maris TG, Zacharopoulou F, Papadakis A, Manolopoulos S, Green S, and Wojnecki C. (2008) Small SRS photon field profile dosimetry performed using a PinPoint air ion chamber, a diamond detector, a novel silicon-diode array (DOSI), and polymer gel dosimetry. Analysis and intercomparison. Medical Physics 35, Issue 10, pp. 4640-4648

O'Hara ME, O'Hehir S, Green S and Mayhew CM (2008) Development of a protocol to measure volatile organic compounds in human breath: a comparison of rebreathing and on-line single exhalations using proton transfer reaction mass spectrometry Physiological Measurement. 29, 309-330  

Kirby D, Green S, Palmans H, Hugtenburg RP, Wojnecki C and Parker DJ, (2010) LET dependence of GafChromic films and an ion chamber in low-energy proton dosimetry, Physics in Medicine and Biology. 55, 417

Fiorini F, Kirby D, Green S and Parker DJ, (2010) Nuclear activation as a current detector for ion beams, Radiation Measurements 45, Issue 10, 1103-1104

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